Special Issue “Saliva and Oral Diseases”

Special Issue

Saliva: A Diagnosis Fluid for Oral and General Diseases

Saliva is considered to be a reliable diagnostic fluid that can replace blood tests in monitoring a number of both oral and systemic diseases. Several aspects of saliva make this fluid one of the top priority biomedical research topics of the 21st century [1]. From a clinical point of view saliva meets one key criteria of an ideal diagnostic fluid: it is a non-invasive fluid. Other characterist...

Special issue on neurodegenerative diseases and their therapeutic approaches

Aging is the strongest risk factor for most neurodegenerative disorders, such as Alzheimer’s disease (AD), Parkinson’s disease, Huntington’s disease and amyotrophic lateral sclerosis. As the aging population is increasing, these neurodegenerative disorders are becoming major social issues in many countries. Interestingly, these diseases share a common pathological phenotype; the accumulation of...

Special Issue: Cellular and Molecular Bases for Fibrotic Diseases

Fibrosis characterizes many chronic diseases that result in end-stage organ failure, causing major morbidity and mortality. Fibrosis in many of these diseases appears to result from aberrant or over-exuberant wound-healing responses to chronic injury, producing excessive accumulation of fibroblasts and extracellular matrix that disrupt normal tissue homeostasis. The potent bioactive lipid lysop...

Special Issue: Inflammatory Bowel Diseases and Intestinal Epithelial Stem Cells

The development of colorectal cancer caused by chronic inflammatory bowel disease (IBD) is the representative example of inflammation-associated carcinogenesis. The mechanism underlying the development of colorectal cancers through chronic inflammation, however, is not known. Activation-induced cytidine deaminase (AID) was originally identified as an inducer of somatic hypermutation in the immu...